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How Kidney Transplant Improves Survival of GPA Patients with Advanced Renal Disease

Kidney Transplant

The kidney is a vital life-sustaining organ that acts as the filter system of the body. It filters and removes fluid, waste, and minerals from the blood through the urine. When the kidneys lose this filtering ability, harmful fluid levels and waste accumulate in the body. It results in high blood pressure and kidney failure. The last stage of kidney disease occurs when it loses 90% ability to function precisely. Thus, it requires a kidney transplant. The Kidney Transplant Cost in India varies according to many factors such as type of transplant, choice of hospital, and more. Undoubtedly, kidney transplant offers several benefits, including survival of Granulomatosis with polyangiitis (GPA). In this article, we will talk about how kidney transplant improves survival of GPA. 

Types of Kidney Transplant

In general, there are three types of kidney transplants. The Kidney Transplant Cost in India differs according to the type of transplant you choose. Let’s have an overview of the three of them.

  • Paired kidney exchange/swap Transplant 

This type of kidney transplantation is for those with unmatched tissue and blood type with the donor. If the donor is not fully compatible with the transplanted kidney, transplantation can still be possible through paired kidney exchange. This type of kidney transplantation can involve two or more people. 

  • Positive Crossmatch and Sensitized Patient Kidney Transplant

This transplantation is for those who have developed antibodies against their donor. Patients receive special treatment in order to decrease their antibody levels. This transplant can be done by removing antibodies from the blood, known as plasmapheresis. Also, when the antibodies in the patient’s body are lowered.

  • Incompatible Blood Type Kidney Transplant

In his transplant, the surgeon eliminates the antibodies of the patient to an incompatible blood type. This transplant lets more people get and benefit from a living donor kidney transplant. In this program, harmful antibodies are removed from patients’ blood. Also, they undergo multiple plasmapheresis treatments prior to the transplantation. The spleen may sometimes have to be removed during the transplant. This is to reduce immune cells that generate antibodies. 

What is Granulomatosis with polyangiitis (GPA)?

GPA is a rare disease characterized by inflammation of various tissues like blood vessels and granulomatous. 

The inflammation of these tissues can damage organ systems such as lungs, kidneys, sinuses, or any other area of the body. 

The common symptoms of GPA are fever, fatigue, weight loss, and loss of appetite. However, when it comes to affecting the kidney, GPA causes kidney inflammation. Also known as nephritis, kidney inflammation is when the functional units of kidneys become inflamed.

Causes of GPA

The causes of GPA are unknown. There is no evidence that it is inherited or contagious. It can lead to harmful inflammatory tissue masses and narrowed, inflamed blood vessels. Moreover, Granulomas can also narrow blood vessels and destroy normal tissue. These can reduce the amount of oxygen and blood that reaches the organs and tissues of the body. Besides affecting the lungs, sinuses, and nose, GPA can also be responsible for kidney damage that requires a kidney transplant. 

Kidney Transplant and Survival of GPA improvement

Kidney disease in GPA is associated with a rapid decline in renal function. It continues to worsen without adequate and timely treatment. Patients with end-stage of kidney disease due to GPA live longer after kidney transplants. In fact, some findings also suggest that kidney transplant is effective for GPA survival. Granulomatosis with polyangiitis (GPA) is a condition that occurs by inflammation of small blood vessels. 

It leads to kidney disease in about 70% of patients. Also, some patients end up developing ESRD (End-stage renal disease). A kidney transplant is the only effective treatment for this condition.

Kidney Transplant Cost in India

Several hospitals in India offer kidney transplants. Some of the biggest hospitals are in New Delhi, Mumbai, Chennai and Bangaluru. 

The kidney transplant cost in India starts from INR 966,000 to 14,86,000. The overall cost depends on several factors. These are the type of transplant/donor, surgeon experience, hospital stay length, room category and more. 

If you are looking for the best hospital for kidney transplants in India, Lyfboat can help! We have listed the major hospitals that specialized in kidney transplants. You can find the best hospital for kidney transplants along with kidney transplant costs in India.

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